Recombinant antigen CagA for Helicobacter pylori

CagA antigen (Cytotoxin-associated gene A) is a protein produced by the bacteria Helicobacter pylori (H. pylori), a pathogen known to cause various gastric diseases, such as gastritis, peptic ulcers and gastric cancer. Not all strains of H. pylori have the cagA gene. Strains that have it are usually associated with greater severity of the disease, being associated with a greater risk of developing more serious conditions, such as peptic ulcers or gastric cancer.

Domain III and the CTD domain (C-terminal domain) are important parts of the CagA protein of Helicobacter pylori, and play key roles in the pathogenicity of this bacterium. Domain III is involved in the initial interaction with host proteins and contains phosphorylation sites critical for CagA activity. The CTD domain is crucial for the translocation, phosphorylation and modulation of cell signaling pathways, contributing to gastric inflammation and carcinogenesis. These characteristics make CagA an important target for diagnostic and therapeutic studies in infections due to H. pylori.

Recombinant antigen for the diagnosis of Helicobacter pylori infection, a human infectious disease.