Multi-epitope recombinant chimeric proteins

At Rekom Biotech, we use computational methods to access structural models of antigenic molecules. This allows us to select specific antigenic domains from different proteins. We then combine them using long, short, flexible, or rigid linkers to enable simultaneous interaction of every epitope with its corresponding paratope. By avoiding steric hindrance, by using the appropriate linker, two or three different antibodies can interact with the multi-epitope molecule, increasing sensitivity. Our chimeric multi-epitope proteins are also highly specific as we select domains that differentiate this microorganism from its counterparts.

In addition, using multi-epitope chimeric proteins has another significant benefit of eliminating the need for protein mixtures in assays. When using protein mixtures, the limited number of binding sites and varying affinities of proteins for these sites may lead to issues with reproducibility.